| 货号 | 15402-1mg |
| 描述 | PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).1,2,3 PSI-7977 is effective in vitroandin vivo.2,4,5 |
| 别名 | GI-7977;Sofosbuvir; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Murakami, E.,Tolstykh, T.,Bao, H., et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. The Journal of Biological Chemisty 285(45), 34337-34347 (2010). 2.Sofia, M.J.,Bao, D.,Chang, W., et al. Discovery of a β-D-2-deoxy-2-α-fluoro-2-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. Journal of Medicinal Chemistry 53(19), 7202-7218 (2010). 3.Lam, A.M.,Espiritu, C.,Bansal, S., et al. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus. Antimicrobial Agents and Chemotherapy 56(6), 3359-3368 (2012). 4.Gane, E.J.,Stedman, C.A.,Hyland, R.H., et al. Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C. New England Journal of Medicine 368(1), 34-44 (2013). 5.Lawitz, E.,Mangia, A.,Wyles, D., et al. Sofosbuvir for previously untreated chronic hepatitis C infection. New England Journal of Medicine 368(20), 1878-1887 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 529.5 |
| 分子式 | C22H29FN3O9P |
| CAS号 | 1190307-88-0 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |