AS-041164
货号：
13622-5mg 基本售价：
812.0 元 规格：
5 mg
产品信息
概述| 货号 | 13622-5mg |
| 描述 | The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism.1 AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC50 = 70 nM), compared to PI3Kα (IC50 = 240 nM), PI3Kβ (IC50 = 1.45 μM), and PI3Kδ (IC50 =1.70 μM).2 When tested at 1.0 μM, it shows little or no activity against 38 other common kinases.2 When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hirsch, E.,Ciraolo, E.,Ghigo, A., et al. Taming the PI3K team to hold inflammation and cancer at bay. Pharmacology & Therapeutics 118, 192-205 (2008).
2.Ferrandi, C.,Ardissone, V.,Ferro, P., et al. Phosphoinositide 3-kinase γ inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. Journal of Pharmacology and Experimental Therapeutics 322, 923-930 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 249.2 |
| 分子式 | C11H7NO4S |
| CAS号 | 6318-41-8 |
| 稳定性 | ≥ 2 years |
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