Atipamezole (hydrochloride)
货号：
9001181-5mg 基本售价：
812.0 元 规格：
5 mg
产品信息
概述| 货号 | 9001181-5mg |
| 描述 | Atipamezole is an imidazole that potently antagonizes the α2-adrenoceptor (Ki = 1.6 nM).1,2 It shows selectivity over the α1-adrenoceptor (Ki = 13,300 nM) and is a poor antagonist at a wide variety of other receptors and channels.2 Through its effects at the α2-adrenoceptor, atipamezole reverses the sedative and analgesic effects of α2-adrenoceptor agonists, alters cognitive functions and sexual behavior, and has neuroprotective effects.2 It may also potentiate the effects of dopaminergic drugs used in Parkinson’s disease.3,2 |
| 别名 | Antisedan®; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Vacher, B.,Funes, P.,Chopin, P., et al. Rigid analogues of the α2-adrenergic blocker atipamezole: Small changes, big consequences. Journal of Medicinal Chemistry 53, 6986-6995 (2010).
2.Pertovaara, A.,Haapalinna, A.,Sirviö, J., et al. Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective α2-adrenoceptor antagonist. CNS Drug Rev. 11(3), 273-288 (2005).
3.Haapalinna, A.,Leino, T., and Heinonen, E. The α2-adrenoceptor antagonist atipamezole potentiates anti-Parkinsonian effects and can reduce the adverse cardiovascular effects of dopaminergic drugs in rats. Naunyn-Schmiedebergs Archives of Pharmacology 368, 342-351 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 248.8 |
| 分子式 | C14H16N2 • HCl |
| CAS号 | 104075-48-1 |
| 稳定性 | ≥ 2 years |
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