| 货号 | 0927/10 |
| 别名 | N-Methyl-3-[(4-trifluoromethyl)phen |
| 供应商 | Tocris |
| 生物活性 | Selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1,α1,α2-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 345.78 |
| 分子式 | C17H18F3NO.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in water |
| CAS号 | 56296-78-7 |
| 参考文献 | Changet al (2010) Increased cellular turnover in response to fluoxetine in neuronal precursors derived from human embryonic stem cells. Int.J.Dev.Biol. 54 707. PMID: 19598107. Becket al (1997) Fluoxetine selectively alters 5-hydroxytryptamine1A and γ-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. J.Pharmacol.Exp.Ther. 281 115. PMID: 9103487. Owenset al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305. PMID: 9400006. Benfieldet al (1986) Fluoxetine. A review of its pharmacodynamic properties, and therapeutic efficacy in depressive illness. Drugs 32 481. PMID: 2878798. |