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货号： bs-2442R 基本售价： 780.0 元 规格： 50ul
- 规格：50ul
- 价格：780.00元
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-2442R
- 英文名称
- MyoD1/Myf3
- 中文名称
- 肌原调节蛋白抗体
- 别 名
- Myogenic differentiation 1; AI503393; bHLHc1; MD1; MGC156574; MYF3; MYOD; MYOD1; PUM; MYOD1_HUMAN; Class C basic helix-loop-helix protein 1; bHLHc1; Myogenic factor 3; Myf-3.
- Specific References (3) | bs-2442R has been referenced in 3 publications.[IF=0.00] Gong, Tao, et al. "The Control of Mesenchymal Stem Cell Differentiation Using Dynamically Tunable Surface Microgrooves." Advanced Healthcare Materials (2014). Rat.PubMed:24648133[IF=2.39] Dai, Yang, et al. "microRNA-128 regulates the proliferation and differentiation of bovine skeletal muscle satellite cells by repressing Sp1." Molecular and Cellular Biochemistry (2016): 1-10. WB ; Bovine.PubMed:26833195[IF=0.00] Shiratsuchi, Takaki, et al. "Sonic Hedgehog Supplementation Rapidly induces Myogenesis in Human Induced Pluripotent Stem Cells." Journal of St. Marianna University 6.2 (2015): 225-233. IF(ICC) ; Human.PubMed:0
- 规格价格
- 50ul/780元购买 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 50ul 100ul 200ul
- 研究领域
- 免疫学 发育生物学 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 35kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse MyoD1:51-150/318
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]
Function:
Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins.
Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1 and CDK9. Interacts with DDX5.
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation.
Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function.
Ubiquitinated on the N-terminus; which is required for proteasomal degradation
Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.
SWISS:
P10085
Gene ID:
17927
Database links:Entrez Gene: 374048 Chicken
Entrez Gene: 281938 Cow
Entrez Gene: 4654 Human
Entrez Gene: 17927 Mouse
Entrez Gene: 407604 Pig
Entrez Gene: 337868 Rat
Entrez Gene: 443405 Sheep
Omim: 159970 Human
SwissProt: P16075 Chicken
SwissProt: Q7YS82 Cow
SwissProt: P15172 Human
SwissProt: P10085 Mouse
SwissProt: P49811 Pig
SwissProt: Q02346 Rat
SwissProt: P29331 Sheep
Unigene: 181768 Human
Unigene: 1526 Mouse
Unigene: 9493 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Sample:
Muscle (Rat) Lysate at 40 ug
Muscle (Mouse) Lysate at 40 ug
Primary: Anti- MyoD1/Myf3 (bs-2442R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 35 kD
Observed band size: 36 kD