Clemastine (fumarate)
货号：
14637-100mg 基本售价：
784.0 元 规格：
100 mg
产品信息
概述| 货号 | 14637-100mg |
| 描述 | Clemastine is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM).1 It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling.2 Clemastine has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kubo, N.,Shirakawa, S.,Kuno, T., et al. Antimuscarinic effects of antihistamines: Quantitative evaluation by receptor-binding assay. Japanese Journal of Pharmacology 43(3), 277-282 (1987).
2.Nörenberg, W.,Hempel, C.,Urban, N., et al. Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations. The Journal of Biological Chemisty 286(13), 11067-11081 (2011).
3.Hartman, V.,Magnussen, H.,Holle, J.P., et al. Modulation of histamine-induced bronchoconstriction with inhaled, oral, and intravenous clemastine in normal and asthmatic subjects. Thorax 36(10), 737-740 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 460 |
| 分子式 | C21H26ClNO • C4H4O4 |
| CAS号 | 14976-57-9 |
| 稳定性 | ≥ 2 years |
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