| 货号 | 9052S |
| 供应商 | CST |
| 背景 | Dasatinib is a small molecule inhibitor of both the Src and Bcr-Abl tyrosine kinases, with IC50 values of 0.55 and 3.0 nM for the isolated kinases, respectively (1). Imatinib and dasatinib have similar inhibitory mechanisms, but dasatinib displays greater potency in imatinib-resistant cell lines and greater inhibitory effect on platelet derived growth factor (PDGF) (2,3). |
| 存放说明 | -20C |
| 参考文献 | 1 . Lombardo, L.J. et al. (2004) J Med Chem 47, 6658-61. 2 . Copland, M. et al. (2006) Blood 107, 4532-9. 3 . Chen, Z. et al. (2006) Mol Pharmacol 69, 1527-33. |
Chemical structure of dasatinib.达沙替尼的化学结构。 |
