AHU377 (calcium salt)
货号：
21473-10mg 基本售价：
770.0 元 规格：
10 mg
产品信息
概述| 货号 | 21473-10mg |
| 描述 | AHU377 is a prodrug of LBQ657 (Item No. 19829), which is an inhibitor of the zinc metallopeptidase neprilysin.1 Neprilysin degrades a variety of vasoactive peptides such as atrial and brain natriuretic peptide, bradykinin, adrenomedullin, and endothelin-1. Inhibition of neprilysin leads to an increased level of these peptides and, thus, antihypertensive effects. Formulations containing AHU377 in combination with the angiotensin II receptor antagonist valsartan (Item No. 14178) are used to treat hypertension and heart failure. |
| 别名 | Sacubitril; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schiering, N.,DArcy, A.,Villard, F., et al. Structure of neprilysin in complex with the active metabolite of sacubitril. Sci.Rep. 6:27909, (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 430.5 |
| 分子式 | C24H28NO5 • 1/2Ca |
| CAS号 | 1369773-39-6 |
| 稳定性 | ≥ 2 years |
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