Etravirine
货号：
20946-5mg 基本售价：
770.0 元 规格：
5 mg
产品信息
概述| 货号 | 20946-5mg |
| 描述 | Etravirine is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits the wild-type enzyme with an EC50 value of 1.4-4.8 nM.1 It also enhances HIV-1 Gag-Pol polyprotein processing in the late stages of HIV-1 replication, resulting in decreased release of viral particles from HIV-1-transfected cells.2,3 |
| 别名 | R165335;TMC125; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Andries, K.,Azijn, H.,Thielemans, T., et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 48(12), 4680-4686 (2004).
2.Figueiredo, A.,Moore, K.L.,Mak, J., et al. Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol. PLoS Pathog. 2(11), e119 (2006).
3.Sluis-Cremer, N. and Tachedjian, G. Mechanisms of inhibition of HIV replication by nonnucleoside reverse transcriptase inhibitors. Virus Res. 134(1-2), 147-156 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 435.3 |
| 分子式 | C20H15BrN6O |
| CAS号 | 269055-15-4 |
| 稳定性 | ≥ 2 years |
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