NS309
货号：
18889-10mg 基本售价：
770.0 元 规格：
10 mg
产品信息
概述| 货号 | 18889-10mg |
| 描述 | NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+(SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels).1,2 It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 µM), but does not, however, affect large conductance (BK/KCa1.1) channels.1,2,3 NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects.1,2 It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO (Item No. 14575) and often used in conjunction with CyPPA (Item No. 15614) to distinguish between SK1 and SK3 subtypes.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pedarzani, P., and Stocker, M. Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain. Cellular and Molecular Life Sciences 65(20), 3196-3217 (2008).
2.Hougaard, C.,Eriksen, B.L.,Jorgensen, S., et al. Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. British Journal of Pharmacology 151(5), 655-665 (2007).
3.Wulff, H., and Köhler, R. Endothelial small-conductance and intermediate-conductance KCa channels: An update on their pharmacology and usefulness as cardiovascular targets. Journal of Cardiovascular Pharmacology 61(2), 102-112 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 231 |
| 分子式 | C8H4Cl2N2O2 |
| CAS号 | 18711-16-5 |
| 稳定性 | ≥ 1 year |
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