| 货号 | 18662-500ug |
| 描述 | 2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry.1,2 Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia.2 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH.3,4 Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50 = ~1.25 mM).5,4,3 |
| 别名 | NSC 270912; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Henry, N.,Delépée, R.,Seigneuret, J.M., et al. Synthesis of water-compatible imprinted polymers of in situ produced fructosazine and 2,5-deoxyfructosazine. Talanta 99, 816-823 (2012). 2.Rodgman, A., and Perfetti, T.A. The chemical components of tobacco and tobacco smoke, Second Edition. Second, (2013). 3.Zhu, A.,Huang, J.B.,Clark, A., et al. 2,5-Deoxyfructosazine, a D-glucosamine derivative, inhibits T-cell interleukin-2 production better than D-glucosamine. Carbohydrate Research 342(18), 2745-2749 (2007). 4.Shimamura, T.,Takamori, A.,Ukeda, H., et al. Reduction mechanism of tetrazolium salt XTT by a glucosamine derivative. Bioscience, Biotechnology, and Biochemistry 67(2), 295-299 (2003). 5.Sumoto, K.,Irie, M.,Mibu, N., et al. Formation of pyrazine derivatives from D-glucosamine and their deoxyribonucleic acid (DNA) strand breakage activity. Chem.Pharm.Bull.(Tokyo) 39(3), 792-794 (1991). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 377.2 |
| 分子式 | C12H20N2O7 • 2HCl |
| CAS号 | 17460-13-8 |
| 稳定性 | ≥ 2 years |
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