TLR4-C34
货号：
18512-5mg 基本售价：
770.0 元 规格：
5 mg
产品信息
概述| 货号 | 18512-5mg |
| 描述 | Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), with LPS-binding protein, to initiate an innate immune response, which typically includes increased expression of TNFα.1 TLR4-C34 is a 2-acetamidopyranoside that inhibits TLR4 signaling in enterocytes and macrophages in vitro when used at 10 µM.2,3 It does not affect signaling through either TLR2 or TLR9. TLR4-C34, used at 1 mg/kg in vivo, also reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.2 It markedly decreases the basal expression of TNFα, as well as LPS-induced iNOS and TNFα expression, in intestinal tissue isolated from patients with necrotizing enterocolitis.2 |
| 别名 | C34;TLR4-IN-C34;Toll-Like Receptor 4-C34; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Morris, M.C.,Gilliam, E.A., and Li, L. Innate immune programing by endotoxin and its pathological consequences. Front.Immunol. 5, 1-8 (2015).
2.Neal, M.D.,Jia, H.,Eyer, B., et al. Discovery and validation of a new class of small molecule toll-like receptor 4 (TLR4) inhibitors. PLoS One 8(6), e65779 (2013).
3.Wipf, P.,Eyer, B.R.,Yamaguchi, Y., et al. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Letters 56(23), 3097-3100 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 389.4 |
| 分子式 | C17H27NO9 |
| CAS号 | 40592-88-9 |
| 稳定性 | ≥ 2 years |
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