| 货号 | 16264-1mg |
| 描述 | Smoothened (Smo) is a GPCR-like receptor that, with Patched, mediates hedgehog (Hh) signaling to regulate gene expression through the Gli transcription factors.1 LY2940680 is an antitumor agent that binds to the human Smo receptor and inhibits Sonic Hh-induced Gli1 expression (IC50 = ~2.4 nM in vitro).2,3,4 The potential anticancer activity of LY2940680 is currently under clinical investigation. |
| 别名 | Taladegib; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ruiz-Gómez, A.,Molnar, C.,Holguín, H., et al. The cell biology of Smo signalling and its relationships with GPCRs. Biochimica et Biophysica Acta 1768(4), 901-912 (2007). 2.Hipskind, P.A.,Patel, B.K. and Wilson, T. Disubstituted phthalazine hedgehog pathway antagonists. PCT/US2010/038568, (2010). 3.Chen, K.C.,Sun, M.F.,Chen, H.Y., et al. Potential smoothened inhibitor from traditional Chinese medicine against the disease of diabetes, obesity, and cancer. Biomed.Res.Int. 2014, 1-12 (2014). 4.Wang, C.,Wu, H.,Katritch, V., et al. Structure of the human smoothened receptor bound to an antitumour agent. Nature 497(7449), 338-343 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 512.5 |
| 分子式 | C26H24F4N6O |
| CAS号 | 1258861-20-9 |
| 稳定性 | ≥ 2 years |
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