CO-1686
货号：
16244-1mg 基本售价：
770.0 元 规格：
1 mg
产品信息
概述| 货号 | 16244-1mg |
| 描述 | CO-1686 is an irreversible kinase inhibitor that specifically targets mutant forms of the epidermal growth factor receptor (EGFR) including T790M (Ki = 21.5 nM) with significantly reduced activity at the wild-type form of the receptor (Ki = 303.3 nM).1 CO-1686 has been shown to inhibit the proliferation of non-small cell lung cancer (NSCLC) cells expressing mutant EGFR with GI50 values ranging from 7-32 nM in vitro, inducing apoptosis.1 It also demonstrates anti-tumor activity in NSCLC EGFR mutant xenograft and transgenic models dosed orally at 100 mg/kg/day.1 |
| 别名 | AVL-301; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Walter, A.O.,Sjin, R.T.T.,Haringsma, H.J., et al. Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. Cancer Discov. 3(12), 1404-1415 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 555.6 |
| 分子式 | C27H28F3N7O3 |
| CAS号 | 1374640-70-6 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
