| 货号 | 16139-50mg |
| 描述 | Pyronaridine (PND) is a potent antimalarial compound developed in China over 40 years ago.1 It inhibits the growth of P. falciparum during the asexual stage and early gametocyte stages (I and II) with an IC50 value of approximately 10 nM.2,3 PND is highly effective against artemisinin-resistant malaria and can be used in combination therapy, particularly with the artemisinin derivative, artesunate (Item No. 11817).4,5 PND, alone or in combination with artesunate, prevents recrudescence of parasites.4 Resistance to pyronaridine may be linked to genetic variations in the P. falciparum multidrug resistance protein 1.3 |
| 别名 | PND; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chang, C.,Lin-Hua, T. and Jantanavivat, C. Studies on a new antimalarial compound: Pyronaridine. Trans.R.Soc.Trop.Med.Hyg. 86(1), 7-10 (1992). 2.Wang, Z.,Liu, M.,Liang, X., et al. A flow cytometry-based quantitative drug sensitivity assay for all Plasmodium falciparum gametocyte stages. PLoS One 9(4), 1-9 (2014). 3.Gupta, B.,Xu, S.,Wang, Z., et al. Plasmodium falciparum multidrug resistance protein 1 (pfmrp1) gene and its association with in vitro drug susceptibility of parasite isolates from north-east Myanmar. Journal of Antimicrobial Chemotherapy 69(8), 2110-2117 (2014). 4.Henrich, P.P.,OBrien, C.,Sáenz, F.E., et al. Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model. Antimicrobial Agents and Chemotherapy 58(1), 183-195 (2014). 5.Pascual, A.,Parola, P.,Benoit-Vical, F., et al. Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum. Malar.J. 11, 1-9 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 910 |
| 分子式 | C29H32ClN5O2 • 4H3PO4 |
| CAS号 | 76748-86-2 |
| 稳定性 | ≥ 2 years |
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