OC000459
货号：
12027-5mg 基本售价：
770.0 元 规格：
5 mg
产品信息
概述| 货号 | 12027-5mg |
| 描述 | OC000459 is a potent, selective DP2 antagonist that displaces [3H]prostaglandin D2([3H]PGD2) from human recombinant DP2 receptors (Ki = 13 nM), rat recombinant DP2 receptors (Ki = 3 nM), and human native DP2(Ki = 4 nM; Th2 cell membranes) without interfering with the ligand binding properties of other prostanoid receptors, including PGE1–4, DP1, TP, PGI2, and PGF.1 OC000459 inhibits chemotaxis and cytokine production of human Th2 lymphocytes with IC50 values of 28 and 19 nM, respectively, and competitively antagonizes eosinophil shape change responses induced by PGD2 in both isolated human leukocytes (pKB = 7.9) and human whole blood (pKB = 7.5).1 OC000459 was shown to inhibit blood eosinophilia in rats induced by 13,14-dihydro-15-keto PGD2 (Item No. 12610) (ED50 = 0.04 mg/kg) and airway eosinophilia in guinea pigs in response to an aerosol of 13,14-dihydro-15-keto PGD2(ED50 = 0.01 mg/kg).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pettipher, R.,Vinall, S.L.,Xue, L., et al. Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. Journal of Pharmacology and Experimental Therapeutics 340(2), 473-482 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 348.4 |
| 分子式 | C21H17FN2O2 |
| CAS号 | 851723-84-7 |
| 稳定性 | ≥ 2 years |
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