Z-Asp-CH2-DCB
货号：
15143-5mg 基本售价：
742.0 元 规格：
5 mg
产品信息
概述| 货号 | 15143-5mg |
| 描述 | Z-Asp-CH2-DCB is a peptide originally synthesized for its ability to inactivate the interleukin-1β-converting enzyme, which is the homolog of the C. elegans positive regulator of apoptosis CED-3.1,2 Z-Asp-CH2-DCB has been shown to block apoptosis by nonselectively inhibiting caspase activity.2 At 1-100 μM, it can dose-dependently block the production of IL-1β, TNF-α, IL-6, and IFN-γ by human peripheral blood mononuclear cells as well as inhibit T cell proliferation.3 |
| 别名 | Z-Asp-2,6-Dichlorobenzoyloxymethyl Ketone; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dolle, R.E.,Hoyer, D.,Prasad, C.V.C., et al. P1 aspartate-based peptide α-((2,6dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1β-converting enzyme. Journal of Medicinal Chemistry 37(5), 563-564 (1994).
2.Mashima, T.,Naito, M.,Kataoka, S., et al. Aspartate-based inhibitor of interleukin-1-β-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells. Biochemical and Biophysical Research Communications 209(3), 907-915 (1995).
3.Krakauer, T. Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation. Clinical and Diagnostic Laboratory Immunology 11(3), 621-624 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 454.3 |
| 分子式 | C20H17Cl2NO7 |
| CAS号 | 153088-73-4 |
| 稳定性 | ≥ 2 years |
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