Mecamylamine (hydrochloride)
货号：
14602-10mg 基本售价：
742.0 元 规格：
10 mg
产品信息
概述| 货号 | 14602-10mg |
| 描述 | Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50 range from 1-7 μM).1 Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine receptors in basic nicotine research. It has been reported to be effective as an aid to smoking cessation and may also be of use in various nicotine-responsive, neuropsychiatric disorders.1,2,3 |
| 别名 | Inversine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Papke, R.L.,Sanberg, P.R. and Shytle, R.D. Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes. Journal of Pharmacology and Experimental Therapeutics 297(2), 646-656 (2001).
2.Damaj, M.I.,Flood, P.,Ho, K.K., et al. Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: In vitro and in vivo selectivity. Journal of Pharmacology and Experimental Therapeutics 312(2), 780-785 (2005).
3.Mineur, Y.S. and Picciotto, M.R. Nicotine receptors and depression: Revisiting and revising the chlorinergic hypothesis. Trends in Pharamacological Sciences 31(12), 580-586 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 203.8 |
| 分子式 | C11H21N • HCl |
| CAS号 | 826-39-1 |
| 稳定性 | ≥ 2 years |
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