| 货号 | 10525-10mg |
| 描述 | Benzodiazepines bind two types of receptors, the central γ-aminobutyric acid A receptor and the peripheral translocator protein (TSPO). PK 11195 binds the peripheral benzodiazepine receptor, TSPO, with selectivity and high affinity (Ki = 3.1 nM in cerebellum, 4.1 nM in spinal cord).1,2 PK 11195, which lacks the 7-member heterocycle of diazepines, blocks binding of typical benzodiazepines to TSPO.1 In addition, the binding of labeled PK 11195 to tissues is used to detect the presence of TSPO by various methods.2,3 PK 11195 has been used to study the ligand binding site of the B. cereusTSPO.4 |
| 别名 | RP 52028; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Watanabe, Y.,Shibuya, T.,Khatami, S., et al. Comparison of typical and atypical benzodiazepines on the central and peripheral benzodiazepine receptors. Japan J.Pharmacol. 42, 189-197 (1986). 2.Pike, V.W.,Halldin, C.,Crouzel, C., et al. Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites-current status. Nuclear Medicine & Biology 20(4), 503-525 (1993). 3.Olson, J.M.M.,Junck, L.,Young, A.B., et al. Isoquinoline and peripheral-type benzodiazepine binding in gliomas: Implications for diagnostic imaging. Cancer Research 48, 5837-5841 (1988). 4.Guo, Y.,Kalathur, R.C.,Liu, Q., et al. Protein structure. Structure and activity of tryptophan-rich TSPO proteins. Science 347(6221), 551-555 (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 352.9 |
| 分子式 | C21H21ClN2O |
| CAS号 | 85532-75-8 |
| 稳定性 | ≥ 2 years |
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