| 货号 | 4506/50 |
| 别名 | N2-[(4-Methylphenyl)sulfonyl]-L-arg |
| 供应商 | Tocris |
| 生物活性 | Competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 = 12 μM) and blocks cyclin degradation in interphase extract. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 378.87 |
| 分子式 | C14H22N4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Zeng & King (2012) An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat.Chem.Biol. 8 383. PMID: 22366722. Zenget al (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 18 382. PMID: 20951947. |