| 货号 | 5359/50 |
| 别名 | (2S,16Z,18E,20S,21S,22R,23R,24R,25S |
| 供应商 | Tocris |
| 生物活性 | Pregnane X receptor (PXR) agonist; antibiotic. Reduces number of colon tumors and suppresses expression of TNFα and Il-1β induced in a colon cancer, PXR-humanized mouse model. Increases apoptosis and decreased proliferation in HT-29 cells. Exhibits low gastrointestinal absorption while retaining its antibacterial activity. Active against gram-positive and gram-negative bacteria. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 785.88 |
| 分子式 | C43H51N3O11< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Chenget al (2014) Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer. J.Pharmacol.Exp.Ther. 351 559. PMID: 25277138. Stradiet al (2010) Structural elucidation of the Rifaximin Ph. Eur. Impurity H. J.Pharm.Biomed.Anal. 51 858. PMID: 19926422. Jianget al (2005) Rifaximin: in vitroandin vivo antibacterial activity-a review. Chemotherapy 51 67. PMID: 15855749. |