| 货号 | 5376/50 |
| 别名 | (3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt |
| 供应商 | Tocris |
| 生物活性 | Highly potent neurosteroid; enhances intracellular Ca2+ upon NMDA receptor-mediated synaptic activity (EC50 = ~2 pM) and potentiates NMDA responses. Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 418.52 |
| 分子式 | C21H31NaO5S |
| 可溶性/溶解性 | Soluble to 10 mM in water with sonication and to 100 mM in DMSO |
| 参考文献 | Smithet al (2014) A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation. Mol.Pharmacol. 86 390. PMID: 25057049. Majeedet al (2010) Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels. Br.J.Pharmacol. 161 430. PMID: 20735426. Liet al (2007) Neuroactive steroids and human recombinant rho1 GABAC receptors. J.Pharmacol.Exp.Ther. 323 236. PMID: 17636008. |