| 货号 | 4979/50 |
| 别名 | 2-Methylpropanedioic acid |
| 供应商 | Tocris |
| 生物活性 | Intracellularly produces malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 118.09 |
| 分子式 | C4H6O4 |
| 可溶性/溶解性 | Soluble to 100 mM in 1.1eq. NaOH and to 100 mM in DMSO |
| 参考文献 | Ehrlich (2012) Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease. Neurotherapeutics 9 270. PMID: 22441874. Beal and Ferrante (2004) Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat.Rev.Neurosci. 5 373. PMID: 15100720. McLaughlinet al (1998) Methylmalonate toxicity in primary neuronal cultures. Neuroscience 86 279. PMID: 9692761. |