| 货号 | 4741/50 |
| 供应商 | Tocris |
| 生物活性 | Calcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 263.61 |
| 分子式 | GdCl3 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| 参考文献 | Del Faveroet al (2012) The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chem.Res.Toxicol. 25 1912. PMID: 22900474. Leeet al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123. PMID: 23143333. Nishitaniet al (2011) Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels. PLoS One. 6 e26181. PMID: 22053183. Nagataet al (2008) The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc.Natl.Acad.Sci.U.S.A. 105 353. PMID: 18162548. |