| 货号 | 4512/50 |
| 别名 | 2(E)-Butenedioic acid 1,4-dimethyl ester; Dimethyl fumarate |
| 供应商 | Tocris |
| 生物活性 | Nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite (MMF, Cat. No. 4511) available. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 144.13 |
| 分子式 | C6H8O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Scannevinet al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274. PMID: 22267202. Linkeret al (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134 678. PMID: 21354971. |