| 货号 | 4981/50 |
| 别名 | 2,2'-Diaminodiethyl disulfide dihydrochloride |
| 供应商 | Tocris |
| 生物活性 | Transglutaminase inhibitor. Attenuates cell death induced by 3-nitropropionic acid (Cat. No. 4849) in Huntington's disease (HD) striatal cells. Also decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Neuroprotective. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 225.2 |
| 分子式 | C4H12N2S2 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Borrell-Pageset al (2006) Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J.Clin.Invest. 116 1410. PMID: 16604191. Maoet al (2006) Cystamine and cysteamine prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells. Eur.J.Neurosci. 23 1701. PMID: 16623826. Dedeogluet al (2002) Therapeutic effects of cystamine in a murine model of Huntington's disease. J.Neurosci. 22 8942. PMID: 12388601. |