| 货号 | 5167/50 |
| 别名 | 3,3'-[(1,1'-Biphenyl)-4,4'-diyl-bis(2, |
| 供应商 | Tocris |
| 生物活性 | VGlut inhibitor; decreases synaptic transmission in the dentate gyrus. Also an amyloid fibril-binding dye; inhibits Fib-beta A neurotoxicity by inhibiting fibril formation or by binding to preformed fibrils. Also inhibits the pancreatic islet cell toxicity of diabetes-associated amylin. Excitation wavelength is 497 nm. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 696.66 |
| 分子式 | C32H22N6Na2< |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 10 mM in DMSO |
| 参考文献 | Nealeet al (2013) Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors. Neuropsychopharmacology. 38 1060. PMID: 23303071. Nealeet al (2013) Effect of VGLUT inhibitors on glutamatergic synaptic transmission in the rodent hippocampus and prefrontal cortex. Neurochem.Int. 73 159. PMID: 24121008. Lorenzoet al (1994) Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc.Natl.Acad.Sci.USA 91 12243. PMID: 7991613. |