| 货号 | 4515/50 |
| 别名 | 2-Deoxy-D-arabino-hexose |
| 供应商 | Tocris |
| 生物活性 | Non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 164.16 |
| 分子式 | C6H12O5 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Ralseret al (2008) A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth. Proc.Natl.Acad.Sci.USA 10517807. Kang and Hwang (2006) 2-deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci. 78 1392. PMID: 16111712. Maheret al (2004) Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer Chemother.Pharmacol. 53 116. PMID: 14605866. |