| 货号 | 14015-5mg |
| 描述 | Kahweol is a natural diterpene that is isolated from coffee beans.1 It increases glutathione S-transferase activity in the gut mucosa of mice and, with the diterpene cafestol, induces glutathione S-transferase expression in rat livers.1,2 Kahweol has anti-inflammatory effects in RAW macrophages, inhibiting LPS-induced nitric oxide and prostaglandin E2 production (IC50 = 54 and 23 μM, respectively).3 Kahweol also is antiangiogenic, blocking the proliferation of endothelial cells (IC50 = 50 μM) and inhibiting endothelial migration, invasion, and tube formation.4 Kahweol is easily oxidized in the presence of air.1 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lam, L.K.T.,Sparnins, V.L. and Wattenberg, L.W. Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse. Cancer Research 42, 1193-1198 (1982). 2.Cavin, C.,Holzhäuser, D.,Constable, A., et al. The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism. Carcinogenesis 19(8), 1369-1375 (1998). 3.Shen, T.,Park, Y.C.,Kim, S.H., et al. Nuclear factor-κB/signal transducers and activators of transcription-1-mediated inflammatory responses in lipopolysaccharide-activated macrophages are a major inhibitory target of kahweol, a coffee diterpene. Biological and Pharmaceutical Bullentin 33(7), 1159-1164 (2010). 4.Cárdenas, C.,Quesada, A.R. and Medina, M.A. Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. PLoS One 6(8), (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 314.4 |
| 分子式 | C20H26O3 |
| CAS号 | 6894-43-5 |
| 稳定性 | ≥ 2 years |
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