Actinomycin D
货号：
11421-5mg 基本售价：
728.0 元 规格：
5 mg
产品信息
概述| 货号 | 11421-5mg |
| 描述 | Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks transcription. It binds to pre-melted double-stranded DNA in transcription bubbles and once bound is slow to dissociate.1,2 DNA in transcriptionally hyperactive cancer cells efficiently and rapidly bind actinomycin D at low concentrations (~10 nM), which interferes with RNA synthesis and ultimately leads to cell death.1,3 Actinomycin D is widely used as an anticancer agent for treating a variety of tumors and along with its fluorescent derivative, 7-aminoactinomycin D (Item No. 11397) has become a useful tool in biochemistry and molecular biology research as a marker for DNA. |
| 别名 | Cosmegen;Dactinomycin;Meractinomycin;NCI C04682;NSC 3053;Oncostatin K; |
| 是否危险品 | 是 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Paramanathan, T.,Vladescu, I.,McCauley, M.J., et al. Force spectroscopy reveals the DNA structural dynamics that govern the slow binding of Actinomycin D. Nucleic Acids Research 40(11), 4925-4932 (2012).
2.Sobell, H.M. Actinomycin and DNA transcription. Proceedings of the National Academy of Sciences of the United States of America 82, 5328-5331 (1985).
3.Choong, M.L.,Yang, H.,Lee, M.A., et al. Specific activation of the p53 pathway by low dose actinomycin D: A new route to p53 based cyclotherapy. Cell Cycle 8(17), 2810-2818 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1255.5 |
| 分子式 | C62H86N12O16 |
| CAS号 | 50-76-0 |
| 稳定性 | ≥ 2 years |
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