| 货号 | 14271-5mg |
| 描述 | W-5 is a chlorine-deficient analog of W-7 (Item No. 14826), a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities (Ki = 11 μM).1,2 W-5 is less active than its calmodulin antagonist counterpart, inhibiting CHO-K1, MCF-7 breast cancer, and human myeloid progenitor cell proliferation with IC50 values greater than 100 μM.1,3,4 As a weaker antagonist for calmodulin, W-5 is suitable for use as a control compound for understanding the specificity of other calmodulin antagonists. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hidaka, H.,Sasaki, Y.,Tanaka, T., et al. N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proceedings of the National Academy of Sciences of the United States of America 78(7), 4354-4357 (1981). 2.Tanaka, T. and Hidaka, H. Hydrophobic regions function in calmodulin-enzyme(s) interactions. The Journal of Biological Chemisty 255(23), 11078-11080 (1980). 3.Gulino, A.,Barrera, G.,Vacca, A., et al. Calmodulin antagonism and growth-inhibiting activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells. Cancer Research 46, 6274-6278 (1986). 4.Katayama, N.,Nishikawa, M.,Komada, F., et al. A role for calmodulin in the growth of human hematopoietic progenitor cells. Blood 75(7), 1446-1454 (1990). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 342.9 |
| 分子式 | C16H22N2O2S • HCl |
| CAS号 | 61714-25-8 |
| 稳定性 | ≥ 2 years |
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