Pifithrin-α
货号：
13326-5mg 基本售价：
714.0 元 规格：
5 mg
产品信息
概述| 货号 | 13326-5mg |
| 描述 | Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.1 It prevents p53-mediated apoptosis induced by cytotoxic compounds in C8 cells at 10 μM 1 and in human umbilical vein endothelial cells at 30 μM.2 Pifithrin-α can also protect cells from DNA damage-induced apoptosis by a p53-independent mechanism that might involve cyclin D1.3 |
| 别名 | PFT-α; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Komarov, P.G.,Komarova, E.A.,Kondratov, R.V., et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285, 1733-1737 (1999).
2.Lorenzo, E.,Ruiz-Ruiz, C.,Quesada, A.J., et al. Doxorubicin induces apoptosis and CD95 gene expressionin human primary endothelial cells through a p53-dependent mechanism. The Journal of Biological Chemisty 277(17), 10883-10892 (2002).
3.Sohn, D.,Graupner, V.,Neise, D., et al. Pifithrin-α protects against DNA damage-inducedapoptosis downstream of mitochondria independentof p53. Cell Death and Differentiation 16, 869-878 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 367.3 |
| 分子式 | C16H18N2OS ?HBr |
| CAS号 | 63208-82-2 |
| 稳定性 | ≥ 2 years |
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