| 货号 | 21415-5mg |
| 描述 | NU 2058 is an inhibitor of cyclin-dependent kinase 1 (Cdk1) and Cdk2 (IC50s = 7.0 and 17 µM, respectively).1,2 Increased Cdk activity is often associated with human tumors, and inhibitors of Cdks, including NU 2058, can arrest cell cycling in cancer cells in vitro.2,3,4 |
| 别名 | O6-(Cyclohexylmethyl)guanine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hardcastle, I.R.,Arris, C.E.,Bentley, J., et al. N2-substituted O6-cyclohexylmethylguanine derivatives: Potent inhibitors of cyclin-dependent kinases 1 and 2. Journal of Medicinal Chemistry 47, 3710-3722 (2004). 2.Sayle, K.L.,Bentley, J.,Boyle, F.T., et al. Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2. Bioorganic & Medicinal Chemistry Letters 13(18), 3079-3082 (2003). 3.Johnson, N.,Bentley, J.,Wang, L.-Z., et al. Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells. Br. J. Cancer 102(2), 342-350 (2010). 4.Rigas, A.C.,Robson, C.N., and Curtin, N.J. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer. Oncogene 26(55), 7611-7619 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 247.3 |
| 分子式 | C12H17N5O |
| CAS号 | 161058-83-9 |
| 稳定性 | ≥ 2 years |
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