| 货号 | 17411-5mg |
| 描述 | 4-P-PDOT is an antagonist of the melatonin 2 (MT2) receptor (pKi = 8.37) that displays 60-fold selectivity for MT2 over MT1.1,2 4-P-PDOT is used in cells, explants, and animals to elucidate the role of MT2 in melatonin-mediated signaling.3,4 |
| 别名 | AH 024;cis-4-phenyl-2-Propionamidotetralin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Browning, C.,Beresford, I.,Fraser, N., et al. Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. British Journal of Pharmacology 129(5), 877-886 (2000). 2.Dubocovich, M.L.,Masana, M.I.,Iacob, S., et al. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn-Schmiedebergs Archives of Pharmacology 355(3), 365-375 (1997). 3.Juszczak, M.,Wolak, M.,Bojanowska, E., et al. The role of melatonin membrane receptors in melatonin-dependent oxytocin secretion from the rat hypothalamo-neurohypophysial system - an in vitro and in vivo approach. Endokrynol. Pol. 67(5), 507-514 (2016). 4.Shin, E.-J.,Chung, Y.-H.,TLe, H.-L.T., et al. Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential. Int. J. Neuropsychopharmacol. 18(6), (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 279.4 |
| 分子式 | C19H21NO |
| CAS号 | 134865-74-0 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |