Dantrolene (sodium salt)
货号：
14326-100mg 基本售价：
700.0 元 规格：
100 mg
产品信息
概述| 货号 | 14326-100mg |
| 描述 | Dantrolene is a skeletal muscle relaxant that depresses excitation-contraction coupling in skeletal muscle by binding to the type 1 ryanodine receptor and decreasing free intracellular calcium concentration.1,2 Dantrolene (10 μM) inhibits L-type currents in developing myotubes by shifting the voltage-dependence of skeletal L-type Ca2+ channel activation to more depolarizing potentials.3 It has been used for the treatment of malignant hyperthermia, the management of neuroleptic malignant syndrome, spasticity, and Ecstasy intoxication.1 |
| 别名 | F 440; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Krause, T.,Gerbershagen, M.U.,Fiege, M., et al. Dantrolene - a review of its pharmacology, therapeutic use and new developments. Anaesthesia 59, 364-373 (2004).
2.Paul-Pletzer, K.,Yamamoto, T.,Bhat, M.B., et al. Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor. The Journal of Biological Chemisty 277(38), 34918-34923 (2002).
3.Bannister, R.A. Dantrolene-induced inhibition of skeletal L-type Ca2+ current requires RyR1 expression. Biomed.Res.Int. 2013, (2013).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 336.2 |
| 分子式 | C14H9N4O5 • Na |
| CAS号 | 14663-23-1 |
| 稳定性 | ≥ 2 years |
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