KL001
货号：
13878-5mg 基本售价：
700.0 元 规格：
5 mg
产品信息
概述| 货号 | 13878-5mg |
| 描述 | The cryptochrome proteins CRY1 and CRY2, which play central roles in maintaining the circadian clock, are expressed and then degraded in a rhythmic pattern.1,2 KL001 is a cell-permeable carbazolic compound which directly interacts with and stabilizes CRY1 and CRY2, preventing ubiquitin-dependent degradation while lengthening the circadian period (IC50 = 0.82-14 μM).2 As the expression of some gluconeogenic genes is both circadian and cryptochrome-dependent, KL001 effectively inhibits glucagon-induced gluconeogenesis in primary hepatocytes.2 This product can be used to study the regulation of cryptochrome-dependent physiology and aid in the development of clock-based therapeutics of diabetes. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Busino, L.,Bassermann, F.,Maiolica, A., et al. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science 316, 900-904 (2007).
2.Hirota, T.,Lee, J.W.,St.John, P.C., et al. Identification of small molecule activators of cryptochrome. Science 337, 1094-1097 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 398.5 |
| 分子式 | C21H22N2O4S |
| CAS号 | 309928-48-1 |
| 稳定性 | ≥ 2 years |
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