Kartogenin
货号：
11826-5mg 基本售价：
700.0 元 规格：
5 mg
产品信息
概述| 货号 | 11826-5mg |
| 描述 | Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM.1 Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ). When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Johnson, K.,Zhu, S.,Tremblay, M.S., et al. A stem cell-based approach to cartilage repair. Science 336, 717-721 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 317.3 |
| 分子式 | C20H15NO3 |
| CAS号 | 4727-31-5 |
| 稳定性 | ≥ 2 years |
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