Endosidin 2
货号：
21888-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 21888-5mg |
| 描述 | Endosidin 2 (ES2) is a cell-permeable benzylidene-benzohydrazide that binds to the exocyst component of the 70 kDA (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1).1 ES2 binding inhibits exocytosis and endosomal recycling in plant and mammalian cells. ES2 disrupts protein trafficking between the endosome and plasma membrane, which enhances trafficking to the vacuole for degradation. It also inhibits recycling of endocytosed transferrin to the plasma membrane in HeLa cells and can target multiple isoforms of mammalian EXO70, resulting in misregulation of exocytosis. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhang, C.,Brown, M.Q.,van de Ven, W., et al. Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis. Proc. Natl. Acad. Sci. USA 113(1), E41-E50 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 414.2 |
| 分子式 | C15H12FIN2O3 |
| CAS号 | 350509-48-7 |
| 稳定性 | ≥ 2 years |
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