| 货号 | 21580-1mg |
| 描述 | Helvolic acid is a mycotoxin originally isolated from A. fumigatus that has broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria.1,2 At 4-16 mg/L, it acted synergistically with erythromycin (500-2,000 mg/L) in vitro on five multi-drug resistant strains of S. aureus.3 At 10 mg/kg/d, it reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma but had no effect when administered alone.4 |
| 别名 | BRN 3230584;Fumigacin;NSC 319943; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chain, E.,Florey, H.W.,Jennings, M.A., et al. Helvolic acid, an antibiotic produced by Apergillus funigatus, mut. helvola Yuill. Br. J. Exp. Pathol. 24(3), 108-119 (1943). 2.Ratnaweera, P.B.,Williams, D.E.,de Silva, E.D., et al. Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka. Mycology 5(1), 23-28 (2014). 3.Qin, L.,Li, B.,Guan, J., et al. In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus. Nat. Prod. Res. 23(4), 309-318 (2009). 4.Xiao, J.-H.,Zhang, Y.,Liang, G.-Y., et al. Synergistic antitumor efficacy of antibacterial helvolic acid from Cordyceps taii and cyclophosphamide in a tumor mouse model. Exp. Biol. Med. (Maywood) 242(2), 214-222 (2017). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 568.7 |
| 分子式 | C33H44O8 |
| CAS号 | 29400-42-8 |
| 稳定性 | ≥ 2 years |
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