RGFP109
货号：
21568-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 21568-5mg |
| 描述 | RGFP109 is a brain-penetrant inhibitor of histone deacetylases (HDACs; IC50s = 60 and 50 nM; Kis = 32 and 5 nM for HDAC1 and HDAC3 in cell-free assays, respectively).1 It has been shown to upregulate frataxin mRNA levels in cultured cells obtained from Friedreich’s ataxia patients and in a GAA repeat-based mouse model of Friedreich’s ataxia.1 |
| 别名 | RG-2833; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rai, M.,Soragni, E.,Chou, C.J., et al. Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich’s ataxia patients and in a mouse model. PLoS One 5(1), e8825 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 339.4 |
| 分子式 | C20H25N3O2 |
| CAS号 | 1215493-56-3 |
| 稳定性 | ≥ 2 years |
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