CpdA
货号：
21438-10mg 基本售价：
686.0 元 规格：
10 mg
产品信息
概述| 货号 | 21438-10mg |
| 描述 | CpdA is a non-steroidal selective glucocorticoid receptor modulator.1 It is an aziridine precursor that can infiltrate cells and is translocated to the nucleus.1,2 It inhibits glucocorticoid receptor dimerization, which prevents transcription of gene targets such as NF-κB and subsequent cytokines through transrepression.3 Studies have shown contradictory results for binding affinity of CpdA compared with dexamethasone (Item No. 11015) that were either higher (4-fold, IC50 = 6.4 nM and 25.9 nM, respectively, in L929sA cells) or lower (63-fold, Kd = 81.8 nM and 1.29 nM, respectively, in BWTG3 cells) in whole cell binding assays.2,3 |
| 别名 | Compound A; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lesovaya, E.,Yemelyanov, A.,Swart, A.C., et al. Discovery of Compound A - a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity. Oncotarget 6(31), 30730-30744 (2015).
2.De Bosscher, K.,Vanden Berghe, W.,Beck, I.M., et al. A fully dissociated compound of plant origin for inflammatory gene repression. Proc. Natl. Acad. Sci. USA 102(44), 15827-15832 (2005).
3.Robertson, S.,Allie-Reid, F.,Vanden Berghe, W., et al. Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound a. J. Biol. Chem. 285(11), 8061-8075 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 264.1 |
| 分子式 | C11H14ClNO2 • HCl |
| CAS号 | 14593-25-0 |
| 稳定性 | ≥ 2 years |
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