Vinorelbine (tartrate)
货号：
21262-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 21262-5mg |
| 描述 | Vinorelbine is a semi-synthetic vinca alkaloid with microtubule destabilizing activity.1,2 It inhibits microtubule polymerization and blocks mitosis at the metaphase/anaphase transition, preventing HeLa cell proliferation with an IC50 value of 1.25 nM.3Inin vitroandin vivo models, vinorelbine has demonstrated additive effects when combined with other antimitotic agents to reduce the proliferation of various solid tumor, lymphoma, or lung cancer cell lines.1 |
| 别名 | KW 2307; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jordan, M.A. and Wilson, L. Microtubules as a target for anticancer drugs. Nature Reviews.Cancer 4(4), 253-265 (2004).
2.Kingston, D.G.I. Tubulin-interactive natural products as anticancer agents. Journal of Natural Products 72(3), 507-515 (2009).
3.Ngan, V.K.,Bellman, K.,Hill, B.T., et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol. Pharmacol. 60(1), 225-232 (2001).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1079.1 |
| 分子式 | C45H54N4O8 • 2C4H6O6 |
| CAS号 | 125317-39-7 |
| 稳定性 | ≥ 2 years |
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