| 货号 | 21121-1g |
| 描述 | Adenosine 5-diphosphate (ADP) is an adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5’ position. It is produced by dephosphorylation of adenosine 5’-triphosphate (ATP; Item No. 14498) by ATPases and can be converted back to ATP by ATP synthases. ADP can also be metabolized to adenosine 5’-monophosphate (AMP; Item No. 21094) and 2’-deoxyadenosine 5’-diphosphate (dADP). ADP can modulate several receptors, activating certain purinergic receptors (EC50 = 24 nM for P2Y1) and inhibiting others (IC50 = 67 nM for P2X2/3), inhibiting rat ecto-5’nucleotidase (Ki = 0.91 nM), and regulating the phosphorylation status of AMP-activated protein kinase (AMPK).1,2,3,4 |
| 别名 | 5-ADP;ADP; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Azran, S.,Förster, D.,Danino, O., et al. Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists. J. Med. Chem. 56(12), 4938-4952 (2013). 2.Baqi, Y.,Lee, S.-Y.,Iqbal, J., et al. Development of potent and selective inhibitors of ecto-5-nucleotidase based on an anthraquinone scaffold. J. Med. Chem. 53(5), 2076-2086 (2010). 3.Jarvis, M.F.,Bianchi, B.,Uchic, J.T., et al. [3H]A-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human P2X2/3 and P2X3 receptors. Journal of Pharmacology and Experimental Therapeutics 310(1), 407-416 (2004). 4.Ruderman, N.B.,Carling, D.,Prentki, M., et al. AMPK, insulin resistance, and the metabolic syndrome. J. Clin. Invest. 123(7), 2764-2772 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 465.3 |
| 分子式 | C10H14N5O10P2 • K |
| CAS号 | 70285-70-0 |
| 稳定性 | ≥ 2 years |
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