LDN-211904
货号：
20453-1mg 基本售价：
686.0 元 规格：
1 mg
产品信息
概述| 货号 | 20453-1mg |
| 描述 | LDN-211904 is an inhibitor of erythropoietin-producing hepatocellular carcinoma (Eph) receptors. In particular, it inhibits EphB3 (IC50 = 79 nM), a tyrosine kinase receptor (RTK) subtype expressed during embryonic development and following central nervous system damage and some cancer cell growth.1 At 5 µM, this compound was profiled for inhibitory activity against a panel of 288 kinases and found to inhibit most of the EphA and EphB receptor kinase subtypes except for EphA6 and EphA7, and is non-inhibitory towards the non-RTKs screened except for p38α, p38β, and Qik.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Qiao, L.,Choi, S.,Case, A., et al. Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioor. Med. Chem. Lett. 19(21), 6122-6126 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 444.9 |
| 分子式 | C19H19ClN4O • C2H2O4 |
| CAS号 | 1198408-78-4 |
| 稳定性 | ≥ 2 years |
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