Spiperone (hydrochloride)
货号：
19769-50mg 基本售价：
686.0 元 规格：
50 mg
产品信息
概述| 货号 | 19769-50mg |
| 描述 | Spiperone is a typical antipsychotic that antagonizes dopamine D2 and serotonin 5-HT2A receptors (Kds = 0.18 and 1 nM, respectively).1,2 It also activates calcium-activated chloride channels (EC50 = 9.3 µM), stimulating chloride secretion in cystic fibrosis (CF) airway epithelial cells and in CF transmembrane conductance regulator knockout mice.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cusack, B.,Nelson, A., and Richelson, E. Binding of antidepressants to human brain receptors: Focus on newer generation compounds. Psychopharmacology (Berl) 114(4), 559-565 (1994).
2.Bonhaus, D.W.,Bach, C.,DeSouza, A., et al. The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: Comparison with 5-HT2A and 5-HT2C receptors. British Journal of Pharmacology 115(4), 622-628 (1995).
3.Liang, L.,MacDonald, K.,Schwiebert, E.M., et al. Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway. Am.J.Physiol.Cell.Physiol. 296(1), C131-C141 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 431.9 |
| 分子式 | C23H26FN3O2 • HCl |
| CAS号 | 2022-29-9 |
| 稳定性 | ≥ 1 year |
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