PTP Inhibitor I
货号：
19766-5g 基本售价：
686.0 元 规格：
5 g
产品信息
概述| 货号 | 19766-5g |
| 描述 | PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 µM and PTP1B with a Ki value of 42 µM.1 SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.2 |
| 别名 | α-Bromo-4-hydroxyacetophenone;2-Bromo-4-hydroxyacetophenone;4-Hydroxyphenacyl bromide;Protein Tyrosine Phosphatase Inhibitor I;SHP-1 Inhibitor II; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Arabaci, G.,Guo, X.C.,Beebe, K.D., et al. αHaloacetophenone derivatives as photoreversible covalent inhibitors of protein tyrosine phosphatases. Journal of the American Chemical Society 121(21), 5085-5086 (1999).
2.Heneberg, P. Use of protein tyrosine phosphatase inhibitors as promising targeted therapeutic drugs. Current Medicinal Chemistry 16(6), 706-733 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 215 |
| 分子式 | C8H7BrO2 |
| CAS号 | 2491-38-5 |
| 稳定性 | ≥ 2 years |
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