MMP-2 Inhibitor I
货号：
19644-5mg 基本售价：
686.0 元 规格：
5 mg
产品信息
概述| 货号 | 19644-5mg |
| 描述 | MMP-2 Inhibitor I is a hydroxamate-based, long-chain fatty acid that acts as a reversible inhibitor of matrix metalloproteinase (MMP)-2 (Ki = 1.6 µM), a protein implicated in the pathological breakdown of extracellular matrix proteins.1 Increased levels of MMP-2 are associated with tumor invasion and metastasis. This compound has been shown to attenuate cancer cell migration.2 It has also been used to preserve blood-brain barrier function in a rat model of pneumococcal meningitis.3 |
| 别名 | Matrix Metalloproteinase-2 Inhibitor I;cis-9-Octadecenoyl-N-hydroxylamide;Oleylhydroxamate; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Berton, A.,Rigot, V.,Huett, E., et al. Involvement of fibronectin type II repeats in the efficient inhibition of gelatinases A and B by long-chain unsaturated fatty acids. The Journal of Biological Chemisty 276(23), 20458-20465 (2016).
2.Emmert-Buck, M.R.,Roth, M.J.,Zhuang, Z., et al. Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples. American Journal of Pathology 145(6), 1285-1290 (1994).
3.Barichello, T.,Generoso, J.S.,Michelon, C.M., et al. Inhibition of matrix metalloproteinases-2 and -9 prevents cognitive impairment induced by pneumococcal meningitis in Wistar rats. Exp.Biol.Med.(Maywood) 239(2), 225-231 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 297.5 |
| 分子式 | C18H35NO2 |
| CAS号 | 10335-69-0 |
| 稳定性 | ≥ 2 years |
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