| 货号 | 19190-5mg |
| 描述 | Cytochromec, which leaks from the mitochondrial intermembrane space into the cytosol, causes oligomerization of apoptotic protease-activating factor 1 (Apaf-1), forming a caspase activation complex known as the apoptosome.1 NS3694 is a cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation.2 It blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with an IC50 value of approximately 50 µM.2 NS3694 prevents the formation of apoptosomes, which prevents the association of procaspases with Apaf-1.2 It suppresses caspase activation and apoptosis in cells treated with either TNF-α or staurosporine (Item No. 81590).2 NS3694 is used to examine the role of apoptosome-mediated caspase activation in cell death.3,4,5 |
| 别名 | Apoptosis Inhibitor II; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Nikoletopoulou, V.,Markaki, M.,Palikaras, K., et al. Crosstalk between apoptosis, necrosis and autophagy. Biochim.Biophys.Acta. 1833(12), 3448-3459 (2013). 2.Lademann, U.,Cain, K.,Gyrd-Hansen, M., et al. Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex. Mol.Cell Biol. 23(21), 7829-7837 (2003). 3.Zhao, C.Q.,Zhang, Y.H.,Jiang, S.D., et al. Both endoplasmic reticulum and mitochondria are involved in disc cell apoptosis and intervertebral disc degeneration in rats. Age (Dordr) 32(2), 161-177 (2010). 4.Miyake, K.,Bekisz, J.,Zhao, T., et al. Apoptosis-inducing factor (AIF) is targeted in IFN-α2a-induced Bid-mediated apoptosis through Bak activation in ovarian cancer cells. Biochimica et Biophysica Acta 1823(8), 1378-1388 (2012). 5.Gauron, C.,Rampon, C.,Bouzaffour, M., et al. Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed. Sci.Rep. 3:2084, (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 358.7 |
| 分子式 | C15H10ClF3N2O3 |
| CAS号 | 426834-38-0 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |