| 货号 | 18821-50mg |
| 描述 | Guanosine 3,5-cyclic monophosphate (cyclic GMP or cGMP) is a second messenger that is biosynthesized from GTP by guanylate cyclases. Activators of guanylate cyclases include nitric oxide and natriuretic peptides.1 cGMP activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation, phototransduction, and energy homeostasis.1,2,3,4 The degradation of cGMP to GMP is mediated by specific and non-specific phosphodiesterases.5,6 |
| 别名 | cGMP;Cyclic guanosine monophosphate;Guanosine 35-cyclic monophosphate;Monosodium-GMP; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hamad, A.M.,Clayton, A.,Islam, B., et al. Guanylyl cyclases, nitric oxide, natriuretic peptides, and airway smooth muscle function. American Journal of Physiology.Lung Cellular and Molecular Physiology 285(5), L973-L983 (2003). 2.Tulis, D.A. Novel therapies for cyclic GMP control of vascular smooth muscle growth. Am.J.Ther. 15(6), 551-564 (2008). 3.Koch, K.W., and DellOrco, D. Protein and signaling networks in vertebrate photoreceptor cells. Front.Mol.Neurosci. 8(67), (2015). 4.Kim, G.W.,Lin, J.E.,Blomain, E.S., et al. Antiobesity pharmacotherapy: New drugs and emerging targets. Clinical Pharmacology and Therapeutics 95(1), 53-66 (2014). 5.DeNinno, M.P. Future directions in phosphodiesterase drug discovery. Bioorganic & Medicinal Chemistry Letters 22(22), 6794-6800 (2012). 6.Rotella, D.P. Phosphodiesterase 5 inhibitors: Current status and potential applications. Nature Reviews.Drug Discovery 1, 674-682 (2002). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 367.2 |
| 分子式 | C10H11N5O7P • Na |
| CAS号 | 40732-48-7 |
| 稳定性 | ≥ 2 years |
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