3-Azido-3-deoxythymidine β-D-glucuronide (sodium salt)
货号：
18679-1mg 基本售价：
686.0 元 规格：
1 mg
产品信息
概述| 货号 | 18679-1mg |
| 描述 | 3-Azido-3-deoxythymidine β-D-glucuronide is a metabolite of the nucleoside reverse transcriptase inhibitor, zidovudine (Item No. 15492), formed by direct conjugation by UDP-glucuronosyltransferase 2B7.1 The azido group of both zidovudine and its glucuronide metabolite can be reduced to an amino group by cytochrome P450 (CYP)3A, CYP2A6, or CYP2B1, forming 3’-amino-3’-deoxythymidine (AMT) and AMT glucuronide, respectively.2 Several compounds, including rifampicin (Item No. 14423), valproic acid (Item No. 13033), fluconazole (Item No. 11594), and efavirenz (Item No. 14412) are known to interfere with zidovudine glucuronidation in vitro in human liver microsomes.2,3 Formation of AMT, which is 5-7-fold more toxic than the parent drug, is thought to be enhanced through inhibition of zidovudine glucuronidation.2 |
| 别名 | AZT glucuronide;Zidovudine glucuronide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Walsky, R.L.,Bauman, J.N.,Bourcier, K., et al. Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors. Drug Metabolism and Disposition 40(5), 1051-1065 (2012).
2.Fayz, S., and Inaba, T. Zidovudine azido-reductase in human liver microsomes: Activation by ethacrynic acid, dipyridamole, and indomethacin and inhibition by human immunodeficiency virus protease inhibitors. Antimicrobial Agents and Chemotherapy 42(7), 1654-1658 (1998).
3.Bélanger, A.S.,Caron, P.,Harvey, M., et al. Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine. Drug Metabolism and Disposition 37(9), 1793-1796 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 465.4 |
| 分子式 | C16H20N5O10 • Na |
| CAS号 | 133525-01-6 |
| 稳定性 | ≥ 2 years |
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